G85R


Fig1. mtDNA Genes cpm in G85R and Silent




Fig2 mtDNA Genes FC in G85R and Silent: log2(FC) for G85R/Silent in Female (xaxis) and Male (yaxis)




Fig3. nucDNA Genes cpm in G85R and Silent: cpm data for nucDNA genes in G85R and Silent. FC of at least 50% in male or female and a mean cpm of at least 10 in 1 of the conditions.




Fig4 nucDNA Genes FC in G85R and Silent: log2(FC) for G85R/Silent in Female (xaxis) and Male (yaxis)



A4V

mtDNA Genes in Head Samples


Fig5. mtDNA Genes cpm in A4V and Silent 3-Day Heads




Fig6 mtDNA Genes FC in A4V and Silent 3-Day Heads: log2(FC) for A4V/Silent in Female (xaxis) and Male (yaxis) 3-Day Heads




Fig7. mtDNA Genes cpm in A4V and Silent 9-Day Heads




Fig8 mtDNA Genes FC in A4V and Silent 9-Day Heads: log2(FC) for A4V/Silent in Female (xaxis) and Male (yaxis) 9-Day Heads




Fig9. mtDNA Genes cpm in A4V and Silent 40-Day Heads




Fig9. mtDNA Genes cpm in A4V and Silent heads at all timepoints



mtDNA Genes in Thorax Samples


Fig10. mtDNA Genes cpm in A4V and Silent 3-Day Thorax




Fig11 mtDNA Genes FC in A4V and Silent 3-Day Thorax: log2(FC) for A4V/Silent in Female (xaxis) and Male (yaxis) 3-Day Thorax




Fig12. mtDNA Genes cpm in A4V and Silent 9-Day Thorax




Fig13 mtDNA Genes FC in A4V and Silent 9-Day Thorax: log2(FC) for A4V/Silent in Female (xaxis) and Male (yaxis) 9-Day Thorax




Fig14. mtDNA Genes cpm in A4V and Silent 40-Day Thorax




Fig15. mtDNA Genes cpm in A4V and Silent thorax at all timepoints



mtDNA Genes in Abdomen Samples


Fig16. mtDNA Genes cpm in A4V and Silent 3-Day Abdomen




Fig17 mtDNA Genes FC in A4V and Silent 3-Day Abdomen: log2(FC) for A4V/Silent in Female (xaxis) and Male (yaxis) 3-Day Abdomen




Fig18. mtDNA Genes cpm in A4V and Silent 9-Day Abdomen




Fig19. mtDNA Genes FC in A4V and Silent 9-Day Abdomen: log2(FC) for A4V/Silent in Female (xaxis) and Male (yaxis) 9-Day Abdomen




Fig20. mtDNA Genes cpm in A4V and Silent 40-Day Abdomen




Fig21. mtDNA Genes cpm in A4V and Silent Abdomen at all timepoints



nucDNA Genes in Head Samples


Fig22a. nucDNA Genes cpm in A4V and Silent 3-Day Heads: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female and a mean cpm of at least 10 in 1 of the conditions and less than 1000 in all of the conditions.




Fig22b. nucDNA Genes cpm in A4V and Silent 3-Day Heads: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female and a mean cpm of at least 1000 in 1 of the conditions.




Fig23 nucDNA Genes FC in A4V and Silent 3-Day Heads: log2(FC) for A4V/Silent in Female (xaxis) and Male (yaxis)




Fig24a. nucDNA Genes cpm in A4V and Silent 9-Day Heads: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female and a mean cpm of at least 10 in 1 of the conditions and less than 1000 in all of the conditions.




Fig24b. nucDNA Genes cpm in A4V and Silent 9-Day Heads: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female and a mean cpm of at least 1000 in 1 of the conditions.




Fig25 nucDNA Genes FC in A4V and Silent 9-Day Heads: log2(FC) for A4V/Silent in Female (xaxis) and Male (yaxis)




Fig26a. nucDNA Genes cpm in A4V and Silent 40-Day Heads: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female and a mean cpm of at least 10 in 1 of the conditions and less than 1000 in all of the conditions.




Fig26b. nucDNA Genes cpm in A4V and Silent 40-Day Heads: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female and a mean cpm of at least 1000 in 1 of the conditions.




Fig27a. nucDNA Genes cpm in A4V and Silent Head at all timepoints: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female for all comparisons and a mean cpm of at least 10 in 1 of the conditions.



nucDNA Genes in Thorax Samples


Fig28a. nucDNA Genes cpm in A4V and Silent 3-Day Thorax: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female and a mean cpm of at least 10 in 1 of the conditions and less than 1000 in all of the conditions.




Fig28b. nucDNA Genes cpm in A4V and Silent 3-Day Thorax: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female and a mean cpm of at least 1000 in 1 of the conditions.




Fig29 nucDNA Genes FC in A4V and Silent 3-Day Thorax: log2(FC) for A4V/Silent in Female (xaxis) and Male (yaxis)




Fig30a. nucDNA Genes cpm in A4V and Silent 9-Day Thorax: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female and a mean cpm of at least 10 in 1 of the conditions and less than 1000 in all of the conditions.




Fig30b. nucDNA Genes cpm in A4V and Silent 9-Day Thorax: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female and a mean cpm of at least 1000 in 1 of the conditions.




Fig31 nucDNA Genes FC in A4V and Silent 9-Day Thorax: log2(FC) for A4V/Silent in Female (xaxis) and Male (yaxis)




Fig32a. nucDNA Genes cpm in A4V and Silent 40-Day Thorax: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female and a mean cpm of at least 10 in 1 of the conditions and less than 1000 in all of the conditions.




Fig32b. nucDNA Genes cpm in A4V and Silent 40-Day Thorax: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female and a mean cpm of at least 1000 in 1 of the conditions.




Fig33a. nucDNA Genes cpm in A4V and Silent Thorax at all timepoints: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female for at least 1 comparison and a mean cpm of at least 10 in 1 of the conditionss and less than 1000 in all of the conditions.




Fig33b. nucDNA Genes cpm in A4V and Silent Thorax at all timepoints: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female for at least 1 comparison and a mean cpm of at least 1000 in 1 of the conditions.



nucDNA Genes in Abdomen Samples


Fig34a. nucDNA Genes cpm in A4V and Silent 3-Day Abdomen: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female and a mean cpm of at least 10 in 1 of the conditions and less than 1000 in all of the conditions.




Fig34b. nucDNA Genes cpm in A4V and Silent 3-Day Abdomen: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female and a mean cpm of at least 1000 in 1 of the conditions.




Fig35 nucDNA Genes FC in A4V and Silent 3-Day Abdomen: log2(FC) for A4V/Silent in Female (xaxis) and Male (yaxis)




Fig36a. nucDNA Genes cpm in A4V and Silent 9-Day Abdomen: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female and a mean cpm of at least 10 in 1 of the conditions and less than 1000 in all of the conditions.




Fig36b. nucDNA Genes cpm in A4V and Silent 9-Day Abdomen: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female and a mean cpm of at least 1000 in 1 of the conditions.




Fig37 nucDNA Genes FC in A4V and Silent 9-Day Abdomen: log2(FC) for A4V/Silent in Female (xaxis) and Male (yaxis)




Fig38a. nucDNA Genes cpm in A4V and Silent 40-Day Abdomen: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female and a mean cpm of at least 10 in 1 of the conditions and less than 1000 in all of the conditions.




Fig38b. nucDNA Genes cpm in A4V and Silent 40-Day Abdomen: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female and a mean cpm of at least 1000 in 1 of the conditions.




Fig39a. nucDNA Genes cpm in A4V and Silent Abdomen at all timepoints: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female for at least 1 comparison and a mean cpm of at least 10 in 1 of the conditionss and less than 1000 in all of the conditions.




Fig39b. nucDNA Genes cpm in A4V and Silent Abdomen at all timepoints: cpm data for nucDNA genes in A4V and Silent. FC of at least 50% in male or female for at least 1 comparison and a mean cpm of at least 1000 in 1 of the conditions.



Specific OXPHOS Complex FC plots


Fig40. OXPHOS Genes cpm in G85R relative to Silent: FC for all OXPHOS with female G85R/WT FC on the x-axis and male G85R/WT on the y-axis. Colors indicate if they were in the GO term for that complex. the “Other” category are genes that were in the OXPHOS GO category but not found in any of the individual complex terms.




Fig41. OXPHOS Genes cpm in A4V relative to Silent 3-Day heads: FC for all OXPHOS with female A4V/WT FC on the x-axis and male A4V/WT on the y-axis. Colors indicate if they were in the GO term for that complex. the “Other” category are genes that were in the OXPHOS GO category but not found in any of the individual complex terms.




Fig42. OXPHOS Genes cpm in A4V relative to Silent 9-Day heads: FC for all OXPHOS with female A4V/WT FC on the x-axis and male A4V/WT on the y-axis. Colors indicate if they were in the GO term for that complex. the “Other” category are genes that were in the OXPHOS GO category but not found in any of the individual complex terms.




Fig43. OXPHOS Genes cpm in A4V relative to Silent 40-day female heads and 9-day male heads: FC for all OXPHOS with 40-day female A4V/WT FC on the x-axis and 9-day male A4V/WT on the y-axis. Colors indicate if they were in the GO term for that complex. the “Other” category are genes that were in the OXPHOS GO category but not found in any of the individual complex terms.




Fig44. OXPHOS Genes cpm in A4V relative to Silent 3-Day thorax: FC for all OXPHOS with female A4V/WT FC on the x-axis and male A4V/WT on the y-axis. Colors indicate if they were in the GO term for that complex. the “Other” category are genes that were in the OXPHOS GO category but not found in any of the individual complex terms.




Fig45. OXPHOS Genes cpm in A4V relative to Silent 9-Day thorax: FC for all OXPHOS with female A4V/WT FC on the x-axis and male A4V/WT on the y-axis. Colors indicate if they were in the GO term for that complex. the “Other” category are genes that were in the OXPHOS GO category but not found in any of the individual complex terms.




Fig46. OXPHOS Genes cpm in A4V relative to Silent 40-day female heads and 9-day male thorax: FC for all OXPHOS with 40-day female A4V/WT FC on the x-axis and 9-day male A4V/WT on the y-axis. Colors indicate if they were in the GO term for that complex. the “Other” category are genes that were in the OXPHOS GO category but not found in any of the individual complex terms.




Fig47. OXPHOS Genes cpm in A4V relative to Silent 3-Day abdomen: FC for all OXPHOS with female A4V/WT FC on the x-axis and male A4V/WT on the y-axis. Colors indicate if they were in the GO term for that complex. the “Other” category are genes that were in the OXPHOS GO category but not found in any of the individual complex terms.




Fig48. OXPHOS Genes cpm in A4V relative to Silent 9-Day abdomen: FC for all OXPHOS with female A4V/WT FC on the x-axis and male A4V/WT on the y-axis. Colors indicate if they were in the GO term for that complex. the “Other” category are genes that were in the OXPHOS GO category but not found in any of the individual complex terms.




Fig49. OXPHOS Genes cpm in A4V relative to Silent 40-day female heads and 9-day male abdomen: FC for all OXPHOS with 40-day female A4V/WT FC on the x-axis and 9-day male A4V/WT on the y-axis. Colors indicate if they were in the GO term for that complex. the “Other” category are genes that were in the OXPHOS GO category but not found in any of the individual complex terms.



Qiagen AD Array Genes

Drosophila Orthologs of the listed Human Genes were collected using GeneCards


Fig50. AD Array Genes cpm in G85R relative to Silent: FC for all AD Array Genes with female G85R/WT FC on the x-axis and male G85R/WT on the y-axis.




Fig51. AD Array Genes cpm in A4V relative to Silent 3-Day heads: FC for all AD Array Genes with female A4V/WT FC on the x-axis and male A4V/WT on the y-axis.




Fig52. AD Array Genes cpm in A4V relative to Silent 9-Day heads: FC for all AD Array Genes with female A4V/WT FC on the x-axis and male A4V/WT on the y-axis.




Fig53. AD Array Genes cpm in A4V relative to Silent 40-day female heads and 9-day male heads: FC for all AD Array Genes with 40-day female A4V/WT FC on the x-axis and male 9-day A4V/WT on the y-axis.




Fig54. AD Array Genes cpm in A4V relative to Silent 3-Day thorax: FC for all AD Array Genes with female A4V/WT FC on the x-axis and male A4V/WT on the y-axis.




Fig55. AD Array Genes cpm in A4V relative to Silent 9-Day thorax: FC for all AD Array Genes with female A4V/WT FC on the x-axis and male A4V/WT on the y-axis.




Fig56. AD Array Genes cpm in A4V relative to Silent 40-day female thorax and 9-day male thorax: FC for all AD Array Genes with 40-day female A4V/WT FC on the x-axis and male 9-day A4V/WT on the y-axis.




Fig57. AD Array Genes cpm in A4V relative to Silent 3-Day abdomen: FC for all AD Array Genes with female A4V/WT FC on the x-axis and male A4V/WT on the y-axis.




Fig58. AD Array Genes cpm in A4V relative to Silent 9-Day thorax: FC for all AD Array Genes with female A4V/WT FC on the x-axis and male A4V/WT on the y-axis.




Fig59. AD Array Genes cpm in A4V relative to Silent 40-day female abdomen and 9-day male abdomen: FC for all AD Array Genes with 40-day female A4V/WT FC on the x-axis and male 9-day A4V/WT on the y-axis.



Specific OXPHOS subset plots

Fig. 60 Genes in G85R that have a FC of at least 50% in male or female relative to silent and a mean cpm of at least 10 in 1 of the conditions. NOTES: CG9005 is a transcriptional regulator of key OXPHOS genes. CG14757 is a SDH assembly factor that als modulates copper ion homeostasis.



Fig. 61 FC of Complex I genes in A4V male and female head samples at 3 day relative to silent. mtDNA encoded genes are in gold. Genes with mean cpm under 10 for all conditions excluded.



Fig. 62 FC of Complex I genes in A4V male and female head samples at 9 day relative to silent. mtDNA encoded genes are in gold. Genes with mean cpm under 10 for all conditions excluded.



Fig. 63 FC of Complex I genes in A4V male 9 day and female 40 day head samples relative to silent. mtDNA encoded genes are in gold. Genes with mean cpm under 10 for all conditions excluded.



Fig. 64 FC of Complex I genes in A4V male 9 day and female 40 day head samples relative to silent. mtDNA encoded genes are in gold. Genes with mean cpm under 10 for all conditions excluded.



Fig. 65 FC of Complex I genes in A4V male and female thorax samples at 3 day relative to silent. mtDNA encoded genes are in gold. Genes with mean cpm under 10 for all conditions excluded.



Fig. 66 FC of Complex I genes in A4V male and female thorax samples at 9 day relative to silent. mtDNA encoded genes are in gold. Genes with mean cpm under 10 for all conditions excluded.



Fig. 67 FC of Complex I genes in A4V male 9 day and female 40 day head samples relative to silent. mtDNA encoded genes are in gold. Genes with mean cpm under 10 for all conditions excluded.



Fig. 68 FC of Complex I genes in A4V male 9 day and female 40 day thorax samples relative to silent. mtDNA encoded genes are in gold. Genes with mean cpm under 10 for all conditions excluded.



Fig. 69 FC of Complex II genes in A4V male and female head samples at 3 day relative to silent. Genes with mean cpm under 10 for all conditions excluded.



Fig. 70 FC of Complex II genes in A4V male and female head samples at 9 day relative to silent. Genes with mean cpm under 10 for all conditions excluded.



Fig. 71 FC of Complex II genes in A4V male 9 day and female 40 day head samples relative to silent. Genes with mean cpm under 10 for all conditions excluded.



Fig. 72 FC of Complex II genes in A4V male 9 day and female 40 day head samples relative to silent. Genes with mean cpm under 10 for all conditions excluded.



Fig. 73 FC of Complex II genes in A4V male and female thorax samples at 3 day relative to silent. Genes with mean cpm under 10 for all conditions excluded.



Fig. 74 FC of Complex II genes in A4V male and female thorax samples at 9 day relative to silent. Genes with mean cpm under 10 for all conditions excluded.



Fig. 75 FC of Complex II genes in A4V male 9 day and female 40 day head samples relative to silent. Genes with mean cpm under 10 for all conditions excluded.



Fig. 76 FC of Complex I genes in A4V male 9 day and female 40 day thorax samples relative to silent. Genes with mean cpm under 10 for all conditions excluded.



Fig. 77 FC of Complex III genes in A4V male and female head samples at 3 day relative to silent. mtDNA encoded genes are in green Genes with mean cpm under 10 for all conditions excluded.



Fig. 78 FC of Complex III genes in A4V male and female head samples at 9 day relative to silent. mtDNA encoded genes are in green Genes with mean cpm under 10 for all conditions excluded.



Fig. 79 FC of Complex III genes in A4V male 9 day and female 40 day head samples relative to silent. mtDNA encoded genes are in green Genes with mean cpm under 10 for all conditions excluded.



Fig. 80 FC of Complex III genes in A4V male 9 day and female 40 day head samples relative to silent. mtDNA encoded genes are in green Genes with mean cpm under 10 for all conditions excluded.



Fig. 81 FC of Complex IV genes in A4V male and female thorax samples at 3 day relative to silent. mtDNA encoded genes are in green Genes with mean cpm under 10 for all conditions excluded.



Fig. 82 FC of Complex IV genes in A4V male and female thorax samples at 9 day relative to silent. mtDNA encoded genes are in green. Genes with mean cpm under 10 for all conditions excluded.



Fig. 83 FC of Complex IV genes in A4V male 9 day and female 40 day head samples relative to silent. mtDNA encoded genes are in green. Genes with mean cpm under 10 for all conditions excluded.



Fig. 84 FC of Complex I genes in A4V male 9 day and female 40 day thorax samples relative to silent. mtDNA encoded genes are in green. Genes with mean cpm under 10 for all conditions excluded.



Fig. 85 FC of Complex IV genes in A4V male and female head samples at 3 day relative to silent. mtDNA encoded genes are in blue Genes with mean cpm under 10 for all conditions excluded.



Fig. 86 FC of Complex IV genes in A4V male and female head samples at 9 day relative to silent. mtDNA encoded genes are in blue Genes with mean cpm under 10 for all conditions excluded.



Fig. 87 FC of Complex IV genes in A4V male 9 day and female 40 day head samples relative to silent. mtDNA encoded genes are in blue Genes with mean cpm under 10 for all conditions excluded.



Fig. 88 FC of Complex IV genes in A4V male 9 day and female 40 day head samples relative to silent. mtDNA encoded genes are in blue Genes with mean cpm under 10 for all conditions excluded.



Fig. 89 FC of Complex IV genes in A4V male and female thorax samples at 3 day relative to silent. mtDNA encoded genes are in blue. Genes with mean cpm under 10 for all conditions excluded.



Fig. 90 FC of Complex IV genes in A4V male and female thorax samples at 9 day relative to silent. mtDNA encoded genes are in blue. Genes with mean cpm under 10 for all conditions excluded.



Fig. 91 FC of Complex IV genes in A4V male 9 day and female 40 day head samples relative to silent. mtDNA encoded genes are in blue. Genes with mean cpm under 10 for all conditions excluded.



Fig. 92 FC of Complex I genes in A4V male 9 day and female 40 day thorax samples relative to silent. mtDNA encoded genes are in blue. Genes with mean cpm under 10 for all conditions excluded.



Fig. 93 FC of Complex V genes in A4V male and female head samples at 3 day relative to silent. mtDNA encoded genes are in red Genes with mean cpm under 10 for all conditions excluded.



Fig. 94 FC of Complex V genes in A4V male and female head samples at 9 day relative to silent. mtDNA encoded genes are in red Genes with mean cpm under 10 for all conditions excluded.



Fig. 95 FC of Complex V genes in A4V male 9 day and female 40 day head samples relative to silent. mtDNA encoded genes are in red Genes with mean cpm under 10 for all conditions excluded.



Fig. 96 FC of Complex V genes in A4V male 9 day and female 40 day head samples relative to silent. mtDNA encoded genes are in red Genes with mean cpm under 10 for all conditions excluded.



Fig. 97 FC of Complex IV genes in A4V male and female thorax samples at 3 day relative to silent. mtDNA encoded genes are in red. Genes with mean cpm under 10 for all conditions excluded.



Fig. 98 FC of Complex IV genes in A4V male and female thorax samples at 9 day relative to silent. mtDNA encoded genes are in red. Genes with mean cpm under 10 for all conditions excluded.



Fig. 99 FC of Complex IV genes in A4V male 9 day and female 40 day head samples relative to silent. mtDNA encoded genes are in red. Genes with mean cpm under 10 for all conditions excluded.



Fig. 100 FC of Complex I genes in A4V male 9 day and female 40 day thorax samples relative to silent. mtDNA encoded genes are in red. Genes with mean cpm under 10 for all conditions excluded.